PROTEIN CRYSTALLISATION

Detailed knowledge of interactions between the structure and function of biomolecules is fundamental for biological, medical and pharmaceutical research. A reliable method is the X-ray structure analysis of protein crystals.

In order to show three-dimensional molecular structures, the proteins must first be crystallised. Since every protein is different and a variety of factors influence protein crystallisation, the optimal conditions are usually tested with high-throughput technologies (pipetting robots). Greiner Bio-One has specially developed microplates and accessories of the CrystalStar series to meet the requirements of high-throughput crystallisation in a short time and with relatively small amounts of protein. Techniques such as vapour diffusion (sitting drop, hanging drop) and microbatch under oil can be carried out effectively.