Drug screening has undergone rapid development over the past years. The number of tests with new targets and the number of active agents to be tested is constantly increasing. Volume reduction, simple testing and cost savings are some of the highest priorities and high-format microplates with a low well volume are one of the most important tools in achieving this. One of the first higher format microplates was the 384 well plate, launched by Greiner Bio-One in 1994/1995.

Compared with the 96 well microplate, the number of wells is quadrupled in this microplate, combined with a volume reduction from 382 μl to 28 μl. The spectrum ranges from standard microplates in clear, black or white to Small Volume microplates and microplates with transparent film bottom. The external dimensions of the 384 well microplates are compatible with automated systems.

Sub Categories

384 Well Microplate Key Facts:

  • Available in polystyrene, polypropylene and cycloolefin
  • Clear / black / white
  • With F-bottom, V-bottom or as Small Volume option
  • Solid bottom, µClear® film bottom or UV-Star® film bottom
  • Sterile / non-sterile
  • Non-treated, in high-binding or non-binding quality

Polystyrene Microplates

  • Clear / black / white
  • F-bottom or Small Volume option
  • With solid bottom or µClear® film bottom
  • Sterile / non-sterile
  • Non-treated or in high-binding quality

Small Volume LoBase Microplates

  • Optimal bottom reading even at low working volumes
  • For transmission / fluorescence / luminescence applications
  • Savings in reagents similar to 1536 well microplates
  • Excellent optical properties
  • Clear, black or white

Small Volume HiBase Microplates

  • Perfect for top reading even at low working volumes
  • For transmission / fluorescence / luminescence applications
  • Savings in reagents similar to 1536 well microplates
  • Excellent optical properties
  • Clear, black or white

Polypropylene Microplates

  • Ideally suited for the storage of active agents, DNA/RNA or stock cultures
  • High chemical resistance and temperature tolerance
  • Natural, black or white

Deep Well Small Volume Polypropylene Microplate

  • Suited for direct compound transfer and preparation of assay-ready plates
  • Large working volume from 1 µl to 90 µl
  • Dead volume below 1 µl
  • No loss of valuable samples

Even more variety with our microplates

  • Ultra-low non-specific binding properties
  • Suited for sensitive biochemical assays
  • Increased assay sensitivity by reducing background and improving signal-to-noise ratio
  • Reliable binding for all types of biotinylated molecules
  • Fast isolation, determination and quantification of components from a reaction mixture
  • Complete reproduction of reaction chains, e.g. enzyme immunoassays
  • Cycloolefin film bottom
  • For measurements of protein concentration at 280 nm
  • Optical window down to 230 nm ideal for nucleic acid determination at 260 nm/280 nm

Well Designs


For precise optical measurements and microscopic applications (bottom reading).

Small Volume LoBase

For bottom reading even at low working volumes.

Small Volume HiBase

For top reading applications even at low working volumes.

Explore our world of microplates

Are you looking for a different well format or surface modification? Choose the right microplate for your specific application with our MICROPLATE FINDER. 

Forum No 16: 96 Well Half Area Microplates and their Application in Fluorescence, Luminescence and Transmission Measurements
Scientific Publications / PDF, 2 MB
Forum No. 20 1536 Well CO Microplate for Compound Storage
Scientific Publications / PDF, 3 MB
Application Note: Establishing a cell culture assay based on time-resolved fluorescence resonance energy transfer (TR-FRET) for screening G-Protein coupled receptors
Scientific Publications / PDF, 445 KB
Labware & Research BioScience Product Catalogue
Product Catalogue / PDF, 37 MB
Application Note: Enhanced Transfection Efficiency on Protein Coated Microplates
Application Notes / PDF, 451 KB
Forum No 6: Sealers for microplates and their areas of application in molecular biology and cell culture
Scientific Publications / PDF, 479 KB
Forum No 11: A New 384 Well Storage Plate Reducing Compound Consumption and Supporting Assay Miniaturisation
Scientific Publications / PDF, 3 MB
Application Note: UV/VIS Spectroscopy in Microplates UV-Star®, µClear®, MICROLON® and CELLSTAR®
Application Notes / PDF, 1 MB
Forum No 15: SCREENSTAR: A new 1536 Well Microplate for High Content and High Throughput Screening
Scientific Publications / PDF, 2 MB
OEM - From standard products to fully customized solutions
Brochure / PDF, 2 MB
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