The core technology of Greiner Bio-One’s Magnetic 3D Cell Culture is the magnetisation of cells with NanoShuttle-PL. The magnetised cells can be aggregated by magnetic forces, either by levitation or bioprinting, to form microphysiologically relevant 3D models in vitro. The magnetic system overcomes the limitations of other platforms by enabling the manipulation of cells for the rapid formation of spheroids, reproducible and scalable in size for high-throughput, without restrictions of cell type.
By levitating cells from the bottom of a cell-repellent plate, magnetic forces work as an invisible scaffold to gently and rapidly aggregate cells, forming larger spheroids at the air-liquid interface, induce cell-cell interactions and initiate ECM synthesis.
With bioprinting magnetised cells are printed into spheroids by placing a cell-repellent plate atop a drive of magnets, where a single magnet below each well utilises mild magnetic forces to induce aggregation and print one spheroid at the bottom of each well within 15 minutes to a few hours.
In addition bioprinting with a spheroidal shape, magnetic printing of cells can also be patterned into a ring formation. For up to 72 hours immediately following bioprinting, the patterned structures will shrink/close as a function of cell migration, viability, cell-cell interaction, and/or proliferation.
In many cases, animal testing is not even necessary, and there are very convincing alternatives - especially three-dimensional (3D) cell culture.
Please contact us if you have any questions regarding our innovative 3D Cell Culture products!
Director of Global Business Development & Innovation 3D Cell Culture
